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Nat Rev Mol Cell Biol. 2011 Jul 13;12(8):535-41. doi: 10.1038/nrm3150.
Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity.
伴侣介导的自噬
Cuervo AM.
Source
Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin Bldg. 504, Bronx, New York 10461, USA. ana-maria.cuervo@einstein.yu.edu.
Abstract
A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.
PMID: 21750569
nrm3150.pdf(1159.53k)
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